Clinical manifestations of ST-elevation myocardial infarction


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Aim of the assessment The purpose of this assessment is to enable you to:
1. Explain the underlying pathophysiology related to the clinical manifestations of ST-elevation myocardial infarction
(STEMI)
2. Discuss the importance of reperfusion in the management of a patient presenting with STEMI
3. Identify evidence-based strategies when caring for a patient presenting with STEMI
PLEASE REFER TO THE ASSESSMENT FOLDER ON VUWS TO ACCESS THE CASE STUDY AND
ECG
Guided Questions:
Question 1: (250 words)
Pick one (1) clinical manifestation and discuss the related pathogenesis:
(i) Central crushing chest pain with radiation to the jaw or;
(ii) ST elevation or;
(iii) elevated Troponin (35ng/L) Question 2: (500 words)
Question 2: (500 words)
Pick one (1) intervention from each of the three (3) categories below.
Provide a rationale for the intervention. Use evidence and/or pathophysiology to support your answer.
Category 1 Non-pharmacological interventions
– Supplemental oxygen if SpO2<93% - 12 lead ECG within 10 minutes of arrival and then every 30 minutes 8 - Troponin at 0 and 2 hours Category 2 Pharmacological interventions - Morphine 2.5mg IV - Nitro-glycerine 600mcg SL - Aspirin 300mg - Heparin 5000iu IV - Clopidogrel 300mg Category 3 Reperfusion interventions - Tenecteplase 45mg IV - Primary Percutaneous Coronary Intervention

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