Assignent Solutionnurs

Perform a literature search using scientific peer-reviewed journals to learn how synapses play a role in one of these developmental disorders, neurodegenerative diseases, psychiatric illnesses.
Choose one of the following 5 diseases to be your focus in your literature research. Based on your interest.
Fragile X Syndrome
Rett Syndrome
Huntington’s Disease
Schizophrenia
Addiction
Only primary empirical studies will be acceptable as your two references. You may consult reviews too, but follow them to the original references. Two references (empirical papers) are required to support your discussion. If the two references’ findings conflict, then feel free to also discuss this conflict.
In your assignment, please state (in your own words, not copied directly from the refs)
1. Provide a short background on the disorder/disease including a short summary of the brain area, cells, and synapses that are implicated in the disease according to the refs you choose to focus on (two sentences approx.). There may be multiple areas implicated but you can focus on one.
(2 pts)
2. Identify TWO synaptic proteins that are implicated in the development or expression of the disease and describe differences (hypothesized or demonstrated) in the diseased and healthy state (can be human or animal model). Three to four sentences for each protein should be enough.
Part 2a, Explain what is thought to be different about the synapses and their function at the intracellular level [at the level of detail we have been learning about in class module 2 and 3, see Ch 11 for example]? (4 pts, 2 for each protein)
Part 2b. How does this change at the synaptic level change affect circuit connectivity and its function? (2 pts, 1 for each protein)
You do have to ensure you find references that discuss proteins that are found in synapses