student 1 post
Tessa Green
Osteoarthritis
Arthritis is characterized as inflammation in the joints and tendons which leads to pain and increased stiffness with motion. Osteoarthritis is a subcategory for Arthritis which directly affects the synovial joints, this takes place at a cellular level, and this causes damage to the cartilage, inflammations new bone formation near the joints, subchondral bone changes and abnormal thickening of the joint capsule (Huether S. 2020 Understanding Pathophysiology Elsevier). This disease can affect any joint, however it is most common in the knees, hips, hands, and spine. Osteoarthritis is the number one condition associated with aging, obesity and bone trauma. As the aging population is more susceptible OA can affect anyone and has no known definitive causes (Hunter, & Bierma-Zeinstra, S. (2019). Osteoarthritis. The Lancet (British Edition), 393(10182), 1745â1759. https://doi.org/10.1016/S0140-6736(19)30417-9.) Risk factors include aging, obesity and continuous strain e.g., football player, runner, doing lots of heavy lifting. Osteoarthritis of the hip and knee are primarily associated with the female sex and obesity. Disease management for OA includes pain management, joint replacement, weight loss, exercise and anti-inflammatory medication among other interventions (Hunter, & Bierma-Zeinstra, S. (2019). Osteoarthritis. The Lancet (British Edition), 393(10182), 1745â1759. https://doi.org/10.1016/S0140-6736(19)30417-9.)
Unfortunately, I have someone in my family that suffers from this disease. Sheâs 55 has OA no prior comorbidities and is now suffering from depression in relation to this disease. OA has completely decreased her quality of life as she is constantly in pain, unable to work, and now walks with a cane at this very young age. I personally have seen her disease drastically progress over the last 4 years and it has been a process for her. Through my nursing career Iâve worked with various patients suffering form this disease and the one most notable thing is pain. These patients experience chronic pain, and there are very few pains free days. OA is terrible and the progression can vary in severity.
Citations
(Hunter, & Bierma-Zeinstra, S. (2019). Osteoarthritis. The Lancet (British Edition), 393(10182), 1745â1759. https://doi.org/10.1016/S0140-6736(19)30417-9.)
(Huether S. McCance K (2020) Understanding Pathophysiology Elsevier)
Kristi Harrison
Osteoarthritis
COLLAPSE
Osteoarthritis is a synovial joint disorder commonly found in the ederly. In the articular cartilage in the synovial joint the tissue homeostasis and the subchondral bone is altered. The extracellular matrix (ECM) sends signals to keep regulation of growth and differentiation of the cartilage homeostasis. During osteoarthritis there’s an imbalance causing wear and tear and pain in the joints. Metalloproteinases (MMPs) and tissue inhibitors metalloproteinases (TIMPs) are the two main enzymes that result in the breakdown of the articular cartilage in osteoarthritis. TGF-beta, IFG, BMP, and NGF also play a role in osteoarthritis, but they do not play a role in repairing the tissue in the articular cartilage. Two recent treatments for osteoarthritis are electric field stimulation and thermal stimulation. As stated in the reading “the electric field stimulation (EFS) effects on cartilage inflammation and the effects of thermal stimulation (TS) on chondrocytesâ apoptosis.” ( Munsterman,S. 2022) Both stimulation were discovered on the understanding of pain management and treatment. As of now I do not know anyone that has osteoarthritis or has been recently diagnosed with osteoarthritis.
Iannone, F., & Lapadula, G. (2003). The pathophysiology of osteoarthritis. Aging Clinical and Experimental Research, 15(5), 364â372. https://doi.org/10.1007/bf03327357
Munsterman, S. (2022). RECENT DISCOVERIES PROVIDE NOVEL TREATMENT FOR OSTEOARTHRITIS. CHIROPRACTIC ECONOMICS, 54â59.