Assignent Solutionnurs

1.       Why are high density lipoproteins (HDLs) considered the €œgood cholesterol€? In your answer explain specifically what HDLs do that cause it to be considered the €œgood cholesterol€.
2.       Why are low density lipoproteins (LDLs) considered the €œbad cholesterol€? In your answer explain specifically what LDLs do that cause it to be considered the €œbad cholesterol€.
3.       What is the role of the phospholipid monolayer at the outer surface of lipoprotein particles? (Question 1 of case study)
4.       Why are cholesterol, cholesteryl esters, and triglycerides preferentially contained inside lipoprotein particles? (Question 2 of case study)
5.       What are the two sources of cholesterol in the human body?
6.       What is a “committed step” in a biochemical pathway? (Question 3 of case study)
7.       Looking at Figure 4 of case study (the reaction pathway from acetyl-CoA), which enzyme is likely to be the target of the statin mevastatin? (Question 6 of case study)
8.       What are four (4) ways that HDL levels can be increased in the body?
9.       What type of inhibitor (non-competitive OR competitive) are statins with respect to HMG-CoA reductase enzyme activity? Explain why.
10.    How were cholesterol-lowering statin drugs first discovered?